Personalise your dietary advice for weight management
DNA Diet Report is designed to help you find the diet type that is most suitable for you, based on your own unique, genetic makeup. Craft a diet plan that will give you the best chance of ensuring healthy, sustainable weight loss
About This Test
DNA Diet is a genetic test designed to guide the personalisation of diet and lifestyle recommendations in order to manage weight. It provides insight into which diet type (low carbohydrate, low fat, or Mediterranean diet) would be most suitable for you according to your unique genetic makeup.
Ideal For
The DNA Diet test is suitable for any individual who is trying to lose weight, or has experienced weight loss resistance in the past, or has tried many different diet types without success, or who simply wants to optimise their macronutrient distribution for improved weight management outcomes. There is no one diet or way of eating that is correct for everyone. DNA Diet will help you understand how your genetic profile can impact your response to different eating plans and which type of diet is best for you.
Report Insights
Test Results
Studies have shown that dietary intake and nutrition knowledge is greatly improved in individuals who received personalised nutrition advice as compared to generalized diet advice.
The selection of genes included in the DNA Diet test have multiple peer review studies examining how variations in these genes contribute to differences in dietary interventions.
These genes impact metabolism, absorption and storage of fats and carbohydrates, to assist in creating a personalized diet plan.
One of the first products of its kind in the world, DNA Diet tests for 15 genes that impact metabolism and exercise. The genes comprising the DNA Diet test have associations with body weight and body mass index, and all meet stringent criteria for utility in genetic screening tests. We provide a detailed report with recommendations that include dietary changes and an exercise programme.
Genes involved in regulation of energy expenditure, appetite, and fat metabolism, all play an important role in weight regulation. In fact 40% to 80% of the variance in body weight is due to genetic factors. This helps to explain why not everyone gains or loses weight while following the same diet, despite being exposed to similar environments. Identifying an individual’s responsiveness to diet and lifestyle modification to control weight can be extremely advantageous.
Genetics determines an individual’s susceptibility to obesity when exposed to an unfavourable environment. It also explores the way a person responds to diet and exercise.
While healthy nutrition may in certain cases result in weight loss, this depends on many factors. The DNA diet provides a tailor made nutrition and exercise programme. Healthy eating and exercise may result in weight loss, but this is not guaranteed.
Clinical Value
- Provides strategies for weight management based on genetic make-up
- Provides motivation to individuals with a goal to lose weight
- Provides an understanding of why previous weight management programmes may have been unsuccessful
- Provides insight to which diet type (i.e. Mediterranean style, low carbohydrate, low fat diet) may be most suited to an individual to manage weight, based on genotype
The DNA Diet Test Report provides:
- The level of impact of any genetic variants identified
- An explanation of their impact on weight management
- Appropriate nutritional and lifestyle recommendations. This includes weight management priorities, diet plan principles, exercise planning and how to calculate MET hours
Tests for:
Genes that impact metabolism, insulin sensitivity, satiety and feeding behaviour.
Analytes measured:
Absorption and Metabolism
FABP2: Influences fat absorption and metabolism.
PPARG: Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids, and is also involved in the regulation of glucose and lipid metabolism.
ADRB2: Involved in the mobilisation of fat from fat cells for energy, in response to catecholamines.
APOA5: Plays an important role in regulation of plasma triglycerides.
Fat Metabolism, Obesity and Satiety
APOA2: An abundant apolipoprotein in HDL. Plays a complex role in lipoprotein metabolism, insulin resistance, obesity and atherosclerosis susceptibility.
Regulation of Metabolism and Feeding Behaviour
MC4R: A strong obesity candidate gene, significantly associated with energy intake and expenditure.
Insulin Sensitivity and Regulation of Energy Intake
FTO: Involved in the regulation of arousal, appetite, temperature, autonomic function and endocrine system.
TCF7L2: Regulates blood glucose homeostasis, influencing both insulin secretion and sensitivity.
Exercise Responsiveness
ADBR3: Involved in the regulation of lypolysis that influences metabolism.
Circadian Rhythms
CLOCK: An essential regulatory arm of the biological clock, involved in metabolic regulation.
Fat Storage
PLIN: Influences diet-induced obesity.
Inflammation
TNF-A: TNFa is a pro-inflammatory cytokine, secreted by both macrophages and adipocytes, which has been shown to alter whole body glucose homeostasis, and has been implicated in the development of obesity, obesity-related insulin resistance and dyslipidemia.
Carbohydrate Sensitivity and Eating Behaviour
TAS1R2: Believed to contribute to the inter-individual variation in sugar consumption.
SLC2A2 (GLUT2): Influences the first step in glucose induced insulin secretion, affecting both food intake and regulation.
DRD2: Midbrain dopamine circuits may play an important role in both addiction and normal eating behaviour as they are involved in reward processing, particularly dopaminergic signalling via dopamine receptor 2 (DRD2).
Test type:
DNA: Gene, diet, exercise, weight management
Sample required:
Bloodspot
Average processing time:
18-21 days
Download sample report
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Privacy policy:
The DNA and the original sample material are destroyed after 3 months, so that there are no names or other identifiers on the samples. The samples are analysed only for the SNPs that are included in the tests at DNALife, and no other research or analyses are performed without a separate permission from the patient. We do not give or sell the results to any third parties.
£170
Please note, the price of this test includes home delivery of test kit and a DHL home collection and shipping to Nordic Laboratories OY in Finland where the samples are processed.
£100
As an add on extra test, please speak to your practitioner for more information about pricing for combining tests
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How it Works
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