In this article:

  • MTHFR & MTRR genes play significant roles in our body, driving methylation, detoxification, and folate metabolism, which are essential for overall health.
  • Genetic variations in these genes can influence these processes, and have been linked with migraine symptoms. Identifying these variants is the first step towards personalized health strategies.
  • DNALife offers tests and reports that can reveal these genetic variants, empowering you with the knowledge to make informed decisions about your health to help reduce migraines.
  • Armed with these insights, you can devise a health plan tailored to your unique genetic makeup, leading to enhanced wellbeing.

Migraines are a common neurological condition affecting millions of people worldwide. They come with a range of symptoms, including intense headache, nausea, and sensitivity to light and sound. While there are medications to help with migraines, many people are now looking into preventing them instead of just numbing the pain. The connection between the MTHFR gene and migraines is one such approach that’s gaining attention. In this blog, we’ll explore what the MTHFR gene is, how it impacts migraines, and what you can do if you have this gene.

Understanding MTHFR Genes


1.  Role and Importance of MTHFR Genes

Firstly, what is the MTHFR gene, and how is it involved with migraines? MTHFR (methylenetetrahydrofolate reductase) is an enzyme encoded by the MTHFR gene. This gene controls a vital process in our bodies called methylation, which is crucial for healthy cell function. Methylation is also important for synthesizing neurotransmitters such as serotonin and dopamine, which regulate our moods and emotions, and help to alleviate pain.

2.  The Process of Methylation and link to Migraines

Now, let’s delve into the methylation process. It’s a simple transfer of four atoms—one carbon atom and three hydrogen atoms—from one substance to another. Sounds simple, right? However, it’s this simple biochemical process that plays a crucial role in maintaining and regulating a wide range of bodily functions—DNA repair, toxin detoxification, stress response, and energy production, to name a few. It’s like the oil that keeps our biological engine running smoothly.


3.  Detoxification and MTHFR Genes

The connection between detoxification and these genes lies within methylation’s broad spectrum of functions. A well-functioning methylation process assists in eliminating toxins and heavy metals from our body, effectively acting as our body’s natural detoxification system.  Recent studies have shown that people with a change (mutation) in the MTHFR gene are at increased risk of migraines. This mutation can affect how efficiently the gene produces the MTHFR enzyme, which, in turn, can impact methylation processes in the body. When methylation is disrupted, it can affect the production of neurotransmitters and increase inflammation in the brain, leading to migraines.



In 22 November 2017, Nature News released a list of the most studied genes in the past 50 years  The TOP10 includes  MTHFR, at number 8 as one of the most studied genes. Source

Studies have attempted to link mutations in MTHFR to over 600 different medical conditions Source

The MTHFR gene has several genotypes, including the 677 CC and 677 TT genotypes. Here are some key differences between these two genotypes:

  • (The 677CC genotype is the wild-type form of the MTHFR gene, while the 677TT genotype is a homozygous variant of the MTHFR gene

  • The 677CC genotype has normal enzyme activity, while the 677TT genotype has less than 30% of the normal enzyme activity
    Sources (1), (2),(3) 

DNA Gene Variants

Decoding the Mystery with DNALife tests and report

1.  Meet DNALife: Your Personal Guide to Genetics

Navigating the complex world of genetics might seem daunting. DNALife, is a leading provider of personalised genetic tests.  Their state-of-the-art genetic tests and detailed reports equip you with invaluable insights into your unique genetic makeup, providing the roadmap to your personal health journey.


2.  Identifying Your Unique Genetic Variants with DNALife

Every one of us is unique, down to our very genes. And it’s in this genetic uniqueness where DNALife excels. Their comprehensive tests can identify variants in key genes, such as MTHFR and MTRR. By uncovering these genetic variants, DNALife gives you a clearer picture of your genetic health profile, empowering you to make more informed health decisions.


3.  Practical Implications of Insights Gained from DNALife

The wealth of insights you gain from DNALife tests goes beyond mere data. It’s about understanding your body’s unique blueprint and how it responds to various influences, be it diet, lifestyle, or environment. Knowing that you carry a certain genetic variant could guide your nutrition choices, like increasing your intake of folate-rich foods if you have an MTHFR variant. DNALife’s reports also offer tangible recommendations tailored to your genetic profile, empowering you to take proactive steps towards a healthier, happier life.

DNA Tests & Reports

DNAHealth: Think of it as your health detective, probing into the complex worlds of lipid metabolism, methylation, inflammation, oxidative stress, and more. Detecting specific APOE gene tweaks that could alter lipid metabolism, it lights up potential risk markers for cardiovascular diseases and Alzheimer’s. Armed with this knowledge, you can strategize lifestyle changes, dietary adjustments, and preventive steps that confront your unique genetic challenges head-on.

DNA Mind is a genetic test that reports on variants in genes that have significant associations with mental health including risk for addictive behaviour, cognitive decline, depression, anxiety and mood regulation.


The MTHFR gene is also reported in the DNA Oestrogen, DNA Mind, DNA Grow Baby,  and DNA Pain.  You can read about the other DNA tests from DNALife here>>

Personalized Health Strategies Based on MTHFR Variants

1.  Leveraging Your Diet for Optimal Health

The good news is that there are practical steps you can take to support healthy methylation processes and reduce your migraine risk. Firstly, a healthy diet rich in folate and other methylation-supporting nutrients, such as vitamin B12, is crucial. Good food sources include leafy greens, beans, whole grains, and seafood. If your diet is low in these nutrients, you might want to consider taking supplements to support methylation.


2.  Avoid Methylation Disruption

Another essential step for those with the MTHFR mutation is to avoid toxins that disrupt methylation. That means reducing exposure to cigarette smoke, pesticides, and processed foods. It’s also crucial to avoid folic-acid-fortified foods or supplements, as they can make matters worse for people with the MTHFR mutation. Instead, opt for folate supplements in the form of methylfolate – the active form of folate that can bypass the disrupted methylation process.


3.  Lifestyle Modifications

In addition to diet and lifestyle changes, some people with the MTHFR mutation might choose to take medications that support methylation processes. Medications require a presciption from a GP, and can help to boost the levels of methylation-supporting nutrients in the body and reduce the risk of migraines.  Other lifestyle modifications can include sleep patterns, stress reduction increasing physical activity including exercise and reducing sedentary activity and screen viewing, eye tests may also be recommended.

Your Next Steps

Migraines are a complex and challenging condition, and there’s no one-size-fits-all solution that works for everyone. However, it’s clear that the MTHFR gene is an essential factor in migraine risk and prevention. By supporting healthy methylation processes through diet, lifestyle, and supplements, people with the MTHFR mutation can take steps to reduce their migraine risk. If you’re struggling with migraines and haven’t yet explored the connection with the MTHFR gene, it’s worth discussing with your healthcare provider or whenever you’re ready, here are 3 ways I can help you:

1) Join The Migraineless Living™ Hub Facebook Page
It’s our Facebook community where people with migraines can learn more about o get more income, impact, and independence. Join us here.
2) Watch The Migraineless Living™ Masterclass
Discover the 4-step method behind our company’s growth and how we help our clients attract A-grade clients like clockwork. Watch it here.
3) Want less migraines…consistently?
If you’re still not seeing the results you want from you current healthy habits and you want a more predictable way to reduce the frequency, duration and intensity of your migraine symptoms (within 8 weeks) without more medications, even if everything you have tried before hasn’t work, then schedule a time to speak with us so we can see if you’re a good fit to work with us.


Why are MTHFR & MTRR genes so important in our bodies?

MTHFR & MTRR genes, are like the conductors of our bodily functions. From managing methylation to supervising detoxification, they are the backstage stars keeping the show running. With their direct impact on folate metabolism, these genes are truly the unsung heroes of our health.

How does a variant in MTHFR & MTRR genes affect our health?

It’s like a slight hiccup in a well-tuned melody. Variations in these genes can cause disruptions in methylation and detoxification processes. Especially when it comes to folate metabolism, these disruptions can significantly influence our wellbeing. Yet, like every coin has two sides, these variants are not necessarily always harmful. They just make us unique, requiring personalized health strategies.

What are DNALIFE health tests, and why should I use them?

I found DNALIFE health tests to be a treasure trove of insights into various genes, It’s a series of tests and reports that help decode your unique genetic information. I feel it gives us an edge, a clear map to navigate our genetic landscape.  Compared to other platforms, DNALIFE offers a comprehensive genetic analysis that focuses more specifically on health, and instead of just telling what gene variants you have, they provide the recommended lifestyle advice via your practitioner providing a more targeted approach.

Which DNALife tests report on the MTHFR and MTRR genes?
Gene  Gene Name Genetic Variation DNA Diet DNA Health DNA Oestrogen DNA Sport DNA Skin DNA Mind DNA Active Grow Baby DNA Smile  DNA Smile Plus DNA Resilience  DNA Pain
Can we really improve our health based on gene variants?

Absolutely, we can! The key is personalisation. Once we know your unique genetic variants, thanks to DNALife, we can craft health strategies tailored to your genetic makeup. It’s like having a secret recipe to a healthier you. It’s exciting and empowering, isn’t it?

Are there any success stories of people improving their health based on genetic variants?

Certainly! Take the case of Sarah, for example. Her DNALife report revealed a variant in her MTHFR gene affecting her folate metabolism. With a few diet adjustments and supplements, she significantly improved her wellbeing. Sarah’s story truly embodies the power of genetic information.